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Short Course 1

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Short Course 3



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Lab-on-a-Chip Workshop

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Short Course 3 - Magnetic Applications in Lab-on-a-Chip

The course is suitable for scientists, technicians and engineers who would like to learn (more) about the applications of magnetic forces within microfluidic lab-on-a-chip devices in particular for applications in the area of life sciences.

Learning Objectives:
  1. Understand the benefits and limitations of utilizing magnetic forces for the manipulation of particles and cells within microfluidic channels.
  2. Understand the underlying principles of magnetic attraction and repulsion.
  3. Gain a broad overview over the applications of magnetic forces within microfluidic devices in the area of life sciences including DNA, protein and cell analysis.
Topics and Course Organisation:

Magnetism and Microfluidics
  1. Motivation for using magnetism basics of magnetic forces (some theory) choice of magnets, choice of magnetic particles
  2. Manipulating magnetic objects pumping, mixing and transfer with magnetic objects particle based reactions/assays/separations magnetically labelled cells magnetic droplets
  3. Manipulating non-magnetic (diamagnetic) objects magnetic repulsion principle particle, cell and droplet focussing and sorting


Lecturers:

Dr Nicole Pamme is a Senior Lecturer in Analytical Chemistry at the University of Hull (UK). Her research is focused on bioanalysis in microfluidic devices with a particular focus on the application of magnetic forces. Teaching activities within the Department include lectures on micro- and nanofluidics as well as microanalytical and forensic chemistry. In addition to publishing in the area of miniaturisation, Nicole Pamme has also co-authored a textbook on bioanalytical chemistry.

Nicole Pamme obtained a Diploma in Chemistry from the University of Marburg (Germany), in 1999. For her PhD she went to Imperial College London (UK) where she joined the group of Prof. Andreas Manz. It was here that she first started working with microfluidic devices, more specifically, on single particle analysis inside microfluidic channels. In 2004, she moved to Tsukuba (Japan) as an independent research fellow in the International Centre for Young Scientists (ICYS) based at the Japanese National Institute for Materials Science. She was appointed as a lecturer in Hull in December 2005.

Dr Mark D. Tarn is a Post Doctoral Research Fellow at the University of Hull (UK). He obtained his MChem degree from Hull in 2007, where he stayed for his PhD under the supervision of Dr Nicole Pamme until 2010. This work concerned the manipulation of particles and cells within microfluidic devices using magnetic forces. Following a short post doctoral position concerning the on-chip purification of radiotracers, in 2011 he moved to KIST Europe (Saarbruecken, Germany) where he worked within the microfluidics group on the development of high-voltage capillary electrophoresis systems. In 2012 he returned to Hull, where he now works on the application of microfluidic devices for the development of radiotracers, and remains involved in a number of projects employing magnetic forces.

Dr Tarn has published extensively on the application of magnetic forces in microfluidic devices, having authored seven papers and delivered several oral presentations on the manipulation of both magnetic and diamagnetic objects. He has also authored two reviews on the manipulation of particles and cells in microchannels, and has authored two book chapters on the field of microfluidics in general.



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