SFC Fluidics
534 W. Res Center Blvd, Suite 260
Fayetteville, AR 72701 USA
phone: 1-479-527-6810
email: info@sfc-fluidics.com
www.sfc-fluidics.com

MINIMIZING EXPERIMENTAL VARIABILITY IN MICROFLUIDICS: ATTAINING ROBUSTNESS, REPRODUCIBILITY AND RELIABILITY
Presenter: Colleen Van Pelt, President

CorSolutions
95 Brown Road, Box 1007
Ithaca, NY 14850 USA
phone: 1-607-351-8028
email: info@mycorsolutions.com
www.mycorsolutions.com

With its diminutive structures, small sample volumes, and low flows, microfluidic experiments are inherently prone to experimental variability. To combat this variability, CorSolutions has developed support hardware which increases robustness, reproducibility and reliability of microfluidic experiments. The hardware includes non-permanent, leak-tight connector probes that seal with the same compressive force every time they are used. And although the sealing force can be changed and optimized for the substrate material, once set, the probe always applies the same compressive force. In addition to connectors, CorSolutions offers high performance fluid delivery pumps. These non-pulsatile pumps offer active-feedback with sensor control, stop-flow capabilities, fast response for fluid rate changes, ability to log flow profiles for traceability, and unprecedented control. As an on-board microprocessor continually monitors flow rate, the flow rate will be maintained regardless if there are changes in the system's backpressure, caused by such things as clogging. With optimal support hardware, experimental variability can be minimized.

Elveflow Microfluidic Innovation Center
Pépinière Paris Santé Cochin
29 rue du Faubourg Saint Jacques
Paris, 75014 FRANCE
phone: +33-184-163-806
email: contact@elveflow.com
www.elveflow.com

HOW THE *§$&"?* DO WE GET THIS TO WORK? DEVELOPMENT STRATEGIES FOR COMPLEX MICROFLUIDIC SYSTEMS
Presenter: Holger Becker, CSO

microfluidic ChipShop
Stockholmer Str. 20
Jena, 07747 GERMANY
phone: +49-364-134-7050
fax: +49-364-1347-0590
email: info@microfluidic-chipshop.com
www.microfluidic-Chipshop.com

Microfluidics has reached a state where the commercialization in many application areas is rapidly advancing. For a true lab-on-a-chip, a high degree of functional integration on the microfluidic device is required and despite the advances in the science and technology of microfluidics, the actual development of such an integrated sample-in answer-out cartridge still is challenging, risk-prone and time consuming. We will present our approach for tackling this challenge, namely by modularizing the development, both for the cartridge as well as the controlling instrument. Based on a tool-kit with modules for a large variety of functions such as mixing, droplet generation, extraction or filters, a stepwise assay validation and subsequent functional integration can be realized rapidly and with reduced development risk. A set of examples from applications such as point-of-care diagnostics, organ-on-a-chip, bioreactors or biothreat monitoring will be given.

thinXXS Microtechnology AG
Amerikastrasse 21
Zweibruecken, 66482 GERMANY
phone: +49-6332-800-20
fax: +49-6332-8002-75
email: info@thinxxs.de
www.thinxxs.com

FLOW CONTROL AND FLUID HANDLING FOR RESEARCH AND INDUSTRIAL PURPOSES
Presenter: Anne Le Nel

Fluigent
Biopark, 1 mail du Professeur Mathé
Villejuif, 94800 FRANCE
phone: +33-17-118-2053
email: contact@fluigent.com
www.fluigent.com

Fluigent has been the first company to handle pressure actuation for microfluidic flow control. Hence we have already distributed our turnkey solution series to hundreds of customers worldwide. In addition to our presentation of our historical FASTABTM technology and our unique Flow-Rate Control Module algorithm that allows flow-rate control with the benefits of pressure actuation, we will present you two main pieces of information about our company. First our new OEM series of all our turnkey products is now available. This new series of Fluigent product is best suited for industrial purpose by its flexibility. Second the opening of two new subsidiaries in Germany, Fluigent GmBH, and Fluigent Inc. in the USA, occurred this year to be closer and closer to our customers.

NEXT GENERATION IN THE MANUFACTURING OF MICRO FLUIDIC DEVICES GLASS IS NOT A COST ISSUE!
Presenter: Alexander Schilling, CEO

Little Things Factory
Ueber der Bitz 3
Elsoff, 56479 GERMANY
phone: +49-2664-239-9390
fax: +49-2664-239-9399
email: info@ltf-gmbh.de www.ltf-gmbh.de

Glass, silicon and quartz are playing an important role as substrate materials for micro fluidic devices. These materials in combination with advanced processing methods lead to a unique mix of feature sizes, optical properties combined with chemical and mechanical resistance at the lower end of the price range, which cannot be achieved by any other material. This presentation outlines the latest generation of structuring methods like glass molding and laser structuring as well as the price range for prototyping and mass production in comparison with other materials.

NEW TECHNOLOGIES AT MICRONIT FOR MICROFLUIDICS AND MEMS APPLICATIONS: HIGHLY PARALLELIZED DROPLET GENERATORS, INTEGRATED PASSIVE FLOW CONTROL, SIDECONNECT INTERFACING, POLYMER AND HYBRID MICROFABRICATION AND MEMS PACKAGING WAFER
Presenter: Marko Blom, Ph.D.

Micronit Microfluidics BV
Colesseum 15
Enschede, 7521 PV THE NETHERLANDS
phone: +34-53-850-6850
fax: +31-53-850-6851
email: info@micronit.com
www.micronit.com

Five new key technology areas at Micronit will be presented:

• Next to our well-known line of droplet generators, Micronit has developed a highly parallelized integrated droplet generator chip, capable of uniformly operating 16 nozzles in parallel on a small footprint.
• Passive capillary stop valves will be shown in combination with electrical triggering, enabling the implementation of more complex laboratory workflows, without the need for mechanical actuation.
• A patent pending SideConnect technology - in addition to the Fluidic Connect Pro platform - minimizes dead volumes and creates a straight uninterrupted flow path.
• Micronit has set up a product development platform for prototyping and medium to high volume manufacturing of microfluidic devices in any kind of material, including various polymers.
• Next to this, Micronit MEMS aims at providing the MEMS industry with structured glass wafers which can be an excellent packaging material for MEMS devices. Technologies include room temperature bonding and Through Glass Vias (TGVs).

ZyGo Corporation
Laurel Brook Road
Middlefield, CT 06455 USA
phone: 1-860-347-8506
fax: 1-860-347-8372
email: inquire@zygo.com
www.zygo.com

DIRECT LASER WRITE FOR MICROFLUIDIC DEVICES
Presenter: Paul Coudray, President of Klöe

OAI
685 River Oaks Parkway
San Jose, CA 95134 USA
phone: 1-408-232-0600
fax: 1-408-433-9904
email: sales@oainet.com
www.oainet.com

Direct Write for microfluidic devices, until now, is difficult due to the high aspect ratios required. The traditional Direct Write Mask Writing System has to make multiple passes in order to write a single microfluidic device. Not only is this time consumming and costly but it also results in rough channel walls in the microfluidic devices. OAI is presenting a new technology: The One-pass Laser Direct Write for microfluidic devices with aspect ratios as high as 20 using 365 or 405nm lasers. This new technology enables microfluidic devices, micro-lenses, diffractive gratings, wave guides, and optical interconnects to be printed in only one pass. In addition, a dual laser system will be discussed which has the capability of writing both high aspect ratio microfluidic devices as well as traditional masks.

World Precision Instruments, Inc.
175 Sarasota Center Blvd.
Sarasota, FL 34240 USA
phone: 1-941-371-1003
fax: 1-941-377-5428
email: tammyv@wpiinc.com
www.wpiinc.com

Cellix Ltd
Longmile Business Centre, Unit 1
Dublin, 12 IRELAND
phone: +353-1-4500-156
fax: +353-1-4500-158
email: info@cellixltd.com
www.cellixltd.com

CD-adapco
60 Broadhollow Road
Melville, NY 11747 USA
phone: 1-631-629-3132
email: info@cd-adapco.com
www.cd-adapco.com

SCIENION
11 Deerpark Drive, Suite 100
Monmouth Junction, NJ 08852 USA
phone: 1-888-988-3842
email: USsupport@scienion.com
www.scienion.com

UNDERSTANDING THE PATHWAYS FROM THE LABORATORY TO REAL WORLD PRODUCTS
Presenter: Erol Harvey

miniFAB
1 Dalmore Drive
Scoresby, VIC 3179 AUSTRALIA
phone: +61-3-9764-2241
fax: +61-3-9764-2663
email: contact@minifab.com.au
www.minifab.com.au

During exciting times of great change and opportunity in lab-on-a-chip enabled healthcare, the pathway to commercialization is crowded with new technologies. It is important to guide travellers through the many risks, technical, financial and regulatory, from laboratory to real world products suitable for the marketplace.

To optimize the chances of successfully reaching the journey's end, you need to clearly define where you're going. Understanding user requirements, adopting a design-for-manufacture approach and having a clear idea of your end-goal can eliminate the many dangers and help avoid the funding 'valley of death'.

Though product development need not be a long journey, it won't be achieved in one giant step. Implementing a staged development strategy segments the pathway into manageable, investible and technically achievable stages, concentrating on risk-based developments as opposed to an agile one. Introducing verification and validation at each stage ensures confidence for your investors, and your product's commercial viability.